Translate:
SEX ANOMALIES
Sex anomalies are biological and are separate from the mental states "transgender" and "non-binary"
- At conception, a person receives one sex chromosome from their father (either X or Y) and one sex chromosome from their mother (always an X).
- If a person has XX sex chromosomes then she is a female and has female primary sex characteristics.
- If a person as XY chromosomes then he is male and has male primary sex characteristics.
- The embryo then receive hormones to cement his or her sex.
- There are rare sex anomalies (biological exceptions).
- However, the sex anomalies / biological exceptions are separate from the mental conditions of "transgender" and "non-binary."
SEX ANOMALIES - CHROMOSOMAL
- Generally, a male has XY sex chromosomes and a female has XX sex chromosomes
- Roughly one in 500 individuals have a sex chromosome anomaly
- These individuals still present as either male (male external genitallia) or female (female external genitalia)
- These anomalies are assigned medical diagnoses
- Signs and symptoms (S/S) occur on a spectrum and some individuals do not have any observable S/S until puberty
- Unfortunately, sex chromosome anomalies are linked to numerous comorbidities and are separate from mental states of "transgenderism" and "non-binary"
SEX ANOMALIES - INTERSEX
- According to intersex model Hanne Gaby Odiele, "some intersex individuals leave medical care altogether because they are so angry at what physicians did to them [surgery to appear more female or more male] before they were the age of consent."
- Odiele's statement illustrates the inappropriateness of "gender affirming care" in children.
- Remember, intersex people have a rare biological condition and are separate from the mental conditions "transgender" and "non-binary."
- Gender ideology abducted the "I," just as they did LGB, but "I" should be part of of the trangender acronym
- AIS occurs in perhaps one in 100,000 individuals
- There are 3 primary types of AIS:nComplete AIS (CAIS), Partial AIS (PAIS), and Mild AIS (MAIS)
- Depending upon the degree of androgen insensitivity, XY chromosome individuals with AIS can present as a male or female or with ambiguous genitalia
- Pictured is model Hanne Gaby Odiele, who has XY sex chromosomes, but presents as a female
- XY chromosome females with AIS always present as a female
INTERSEX - Disorders of Sexual Differentiation (DSD)
aka Ambiguous Genitalia
- The external genitalia are neither fully male nor female
- Occurs in one in 5,000 live births
Pediatricians must assign Sex if genitalia is ambiguous
Case Report of a Person with Ambiguous Genitalia
Case Report of a Person with Ambiguous Genitalia
(a) Female external genitalia with clitoromegaly (b) Postoperative photograph after vaginoplasty and reduction of the enlarged clitoris (c) Gross specimen showing female (♀) and male (♂) parts of ovotestis (d) Cut surface of gross specimen showing grayish white, yellowish areas intersected by darker areas
Androgen Insensitivity Syndrome (AIS)
- Occurs in one in 20,000 to 64,000 XY sex chromosome individuals
- These XY chromosome individuals can present as a male or female or ambiguous
- There are over 150 different defects that have been identified so far, and each causes a different type of AIS, e.g., CAIS, PAIS, and MAIS
CAIS (complete AIS), aka Morris Syndrome
- Individual has XY sex chromosomes, but presents as a female
- One in every 80,000 live births
- X-linked recessive condition due to a complete or partial insensitivity to androgens
- Results in a failure of normal masculinization of the external genitalia XY sex individuals
SEX ANOMALY - XY FEMALE
Swyer Syndrome
- Individual has XY sex chromosomes, but presents as a female
- Occurs in one in 20,000 live births
- The cause is often unknown
- However, in about 15% of cases it is due to a mutation in the SRY gene
- The SRY gene, located on the Y chromosome, provides instructions for making a protein called sex-determining region Y
SEX ANOMALY - XX MALE
de la Chapelle Syndrome
- One in 80,000 live births
- Two X sex chromosomes in each cell, but invariably have male external genitallia, ranging from normal to atypical with associated testosterone deficiency.
- The testes are small and undescended (cryptorchidism) or the urethra opening is on the underside of the penis (hypospadias).
- A small number of affected people have ambiguous genitalia.
- Their internal sex organs do not form normally and might not even be present.
- This exchange occurs as a random event during the formation of sperm cells in the affected person's father. The translocation causes the SRY gene to be misplaced, almost always onto an X chromosome. If a fetus is conceived from a sperm cell with an X chromosome bearing the SRY gene, it will develop as a male despite not having a Y chromosome.